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These results reveal that PMNs efficiently blunt HIV-1 replication in primary target cells and tissue by an unconventional mechanism. Keywords: HIV-1 replication, polymorphonuclear neutrophils, antiviral activity, human tonsil explant culture Graphical abstract Open in a separate window Introduction Invading pathogens face a wide range of innate and adaptive immune responses that need to be bypassed or counteracted for efficient spread in the new host. In this tug-of-war between pathogen and host, polymorphonuclear neutrophils PMNs , the most abundant human white blood cells, are considered a first line of host defense.

High numbers of PMNs are recruited rapidly to sites of infection or sterile injury, where they can survive for as long as 7 days to exert potent anti-microbial activities. This scenario particularly applies to human immunodeficiency virus type 1 HIV-1 , the causative agent of AIDS; host responses to acute HIV-1 infection are thought to be dominated by innate immune-sensing events and cell-intrinsic antiviral factors restriction factors.

We find that PMNs exert immediate and potent anti-HIV-1 activity that requires direct cell-cell contact but is not mediated by any of the classic PMN effector functions described so far. We therefore used ex vivo cultures of human tonsil tissue as a model system that allows following HIV-1 spread and associated CD4 T cell depletion in a natural HIV-1 target tissue explant without the need for experimental cell activation, thus serving as an approximation of HIV infection of lymphoid tissue.

Seminars, workshops, studio visits and events will cover all aspects of the international film business - from development through production, financing, worldwide distribution, marketing and exhibition and the latest digital developments.

Nik Powell, NFTS Director, said: "The eleventh edition of Inside Pictures will welcome a great mix of top level participants from across Europe, and we are looking forward to a very strong year. The impressive accomplishments of Inside Pictures' alumni network are a testament to the quality of the course and its participants.

Julia Short, Inside Pictures Programme Director of Content, said "The Inside Pictures programme develops the business and leadership skills necessary to succeed in a rapidly changing industry and world market. Each of the selected Inside Pictures Participants brings a unique set of skills and experiences to the group, and we are privileged to have a range of top levels speakers from around the world lending their expertise to the programme.

We are tremendously excited to see what this year's group achieve, both during the programme and in their subsequent careers as film industry leaders.

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For example, go to Netflix and choose any show you would like to watch and start playing the video. Open a video 3. Create a Teleparty 3. Create a Teleparty. To create your party, click on the red "NP" icon located next to the address bar. Create a Teleparty 4. To create your party, click on the red "Tp" icon located next to the address bar.

Join a Teleparty 4. Join a Teleparty. To join a party click on the party URL, which will redirect to a video on a streaming website. Then click on the "NP" button next to the address bar, and you should automatically join the party. Join a Teleparty 5. To join a party click on the party URL, which will redirect to Netflix's website.

Then click on the "Tp" button next to the address bar, and you should automatically join the party. That means if one person pauses, it pauses for everyone else as well. So think twice before you hit the spacebar to grab yourself some extra snacks. This is also what makes it a far better option than starting a Zoom or Skype meeting and trying to make sure everyone hits the play button at the same time, which never works.

When they join, Teleparty syncs the movie for everyone and lets you chat with each other in the sidebar. Related: How to Use Netflix Party to Watch Movies Together Online Over 10 million people have used Teleparty for long-distance movie nights, and all you need to do to join them is install the free browser extension in Google Chrome.

After adding the extension, just find a movie, click the extension to create a party, and share your link. This feature is available on a computer, in the mobile app, and on Fire TV devices. On the upside, Watch Party promises to let you chat with up to friends at once and works with any movies or TV shows included with Prime.